Although advanced breast cancer is not curable, treatments can help prolong life, manage symptoms and improve quality of life. Potential benefits of treatment must be outweighed by the associated toxicity. Treatment is continued until there is evidence of disease progression or the patient develops unacceptable toxicity. Research has improved our understanding of breast cancer subtypes, treatment resistance and prognostic biomarkers and has led to the discovery of novel targeted therapies. The general practitioner (GP) is an important team member for women in the community living with advanced breast cancer.